Chloro-Furanocembranolides from Leptogorgia sp Improve Pancreatic Beta-Cell Proliferation

Gallardo Ovando, Amalia Beatriz; Diaz-Marrero, Ana R.; de la Rosa, Jose M.; D'Croz, Luis; Perdomo, German; Cozar-Castellano, Irene; Darias, Jose; Cueto, Mercedes

doi:10.3390/md16020049

Chloro-Furanocembranolides from Leptogorgia sp Improve Pancreatic Beta-Cell Proliferation

Gallardo Ovando, Amalia Beatriz

[1];

Diaz-Marrero, Ana R.

[2];

de la Rosa, Jose M.

[2];

D'Croz, Luis

[3];

Perdomo, German

[4];

Cozar-Castellano, Irene

[5];

Darias, Jose

[2];

Cueto, Mercedes

[2]

¹
Departamento de Ciencias y Recursos Naturales
²
Consejo Superior de Investigaciones Cientificas (CSIC)
³
Universidad de Panama
⁴
Universidad de Burgos
⁵
Universidad de Valladolid

DOI

10.3390/md16020049

Date Issued

2018-2

Type

Artículo

Journal

Marine Drugs

ISSN

1660-3397

Open Access

gold

Volume

16

Links

https://arca.umag.cl/handle/123456789/13628

Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells.

leptogorgia

cembranolides

furanocembranolides

diketocembranolides

seco-furanocembranoli...

chloro-furanocembrano...

pancreatic beta-cells...