LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
Prieto, Daniel
Pasteur Network
Seija, Noe
Pasteur Network
Uriepero, Angimar
Pasteur Network
Souto-Padron, Thais
Universidade Federal do Rio de Janeiro
Oliver, Carolina
Universidad de la Republica, Uruguay
Irigoin, Victoria
Universidad de la Republica, Uruguay
Guillermo, Cecilia
Universidad de la Republica, Uruguay
Ines Landoni, Ana
Hosp Maciel
Dighiero, Guillermo
Hosp Maciel
Gabus, Raul
Hosp Maciel
Giordano, Mirta
Buenos Aires National Academy of Medicine
Oppezzo, Pablo
Pasteur Network
Journal
British Journal of Haematology
ISSN
0007-1048
1365-2141
Open Access
bronze
Volume
182
Start page
521
End page
525
Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not express LPL mRNA. Our results show that LPL protein is differently located in CLL cells depending on whether it is incorporated from the extracellular medium in mutated CLL or generated de novo by leukaemic cells of unmutated patients. The specific quantification of endogenous LPL protein correlates with mRNA expression levels and mutational IGHV status, suggesting LPL protein as a possible reliable prognostic marker in CLL.