Chloro-Furanocembranolides from Leptogorgia sp Improve Pancreatic Beta-Cell Proliferation
Diaz-Marrero, Ana R.
Consejo Superior de Investigaciones Cientificas (CSIC)
de la Rosa, Jose M.
Consejo Superior de Investigaciones Cientificas (CSIC)
D'Croz, Luis
Universidad de Panama
Perdomo, German
Universidad de Burgos
Cozar-Castellano, Irene
Universidad de Valladolid
Darias, Jose
Consejo Superior de Investigaciones Cientificas (CSIC)
Cueto, Mercedes
Consejo Superior de Investigaciones Cientificas (CSIC)
Journal
Marine Drugs
ISSN
1660-3397
Open Access
gold
Volume
16
Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells.