A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea
Cretton, Sylvian
University of Lausanne
Righi, Davide
University of Lausanne
Sahib, Lamia
University of Lausanne
Kaiser, Marcel
University of Basel
Christen, Philippe
University of Lausanne
Journal
Natural Product Research
ISSN
1478-6419
1478-6427
Open Access
closed
Volume
32
Start page
695
End page
701
A new bibenzyl derivative (4), together with two glycosylated flavonoids (1 and 2), batatasin III (3) and the phenanthrene isohircinol (5) were isolated from the aerial parts of Gavilea lutea. Their structures were elucidated on the basis of spectroscopic studies including 1D and 2D NMR, UV, IR and HRESIMS. All isolated compounds were evaluated for their antifungal activity towards Candida albicans. The new compound 4 showed inhibitory activity with a MIQ of 50 mu g. In addition, compound 4 exhibited a selective activity (IC50 = 2.3 mu g/mL) against Leishmania donovani. [GRAPHICS] .
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