Oscillatory pattern of glycemic control in patients with diabetes mellitus
Vasquez-Munoz, Manuel
Clin Santa Maria
Arce-Alvarez, Alexis
Universidad Catolica Silva Henriquez
von Igel, Magdalena
Universidad Mayor
Veliz, Carlos
Universidad Mayor
Ruiz-Esquide, Gonzalo
Clin Santa Maria
Ramirez-Campillo, Rodrigo
Universidad Mayor
Alvarez, Cristian
Universidad de Los Lagos
Ramirez-Velez, Robinson
Navarrabiomed
Crespo, Fernando A.
Universidad Mayor
Izquierdo, Mikel
Navarrabiomed
Andrade, David C.
Universidad Mayor
Journal
Scientific Reports
ISSN
2045-2322
Open Access
gold
Volume
11
Daily glucose variability is higher in diabetic mellitus (DM) patients which has been related to the severity of the disease. However, it is unclear whether glycemic variability displays a specific pattern oscillation or if it is completely random. Thus, to determine glycemic variability pattern, we measured and analyzed continuous glucose monitoring (CGM) data, in control subjects and patients with DM type-1 (T1D). CGM data was assessed for 6 days (day: 08:00-20:00-h; and night: 20:00-08:00-h). Participants (n =172; age =18-80 years) were assigned to T1D (n =144, females = 65) and Control (i.e., healthy; n = 28, females = 22) groups. Anthropometry, pharmacologic treatments, glycosylated hemoglobin (HbA1c) and years of evolution were determined. T1D females displayed a higher glycemia at 10:00-14:00-h vs. T1D males and Control females. DM patients displays mainly stationary oscillations (deterministic), with circadian rhythm characteristics. The glycemia oscillated between 2 and 6 days. The predictive model of glycemia showed that it is possible to predict hyper and hypoglycemia (R-2 =0.94 and 0.98, respectively) in DM patients independent of their etiology. Our data showed that glycemic variability had a specific oscillation pattern with circadian characteristics, with episodes of hypoglycemia and hyperglycemia at day phases, which could help therapeutic action for this population.
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